Maslinic Acid Reduces Blood Glucose in KK-A^y Mice

抄録

In the present study, we have examined the hypoglycemic effect of maslinic acid (MA) in KK-A^y mice, an animal model of genetic type-2 diabetes. MA (10 mg/kg body wt) reduced the blood glucose levels in KK-A^y mice at 4 h after a single oral dose. KK-A^y mice receiving MA at daily dosages of 10 mg/kg and 30 mg/kg for 2 weeks showed a significant reduction in the blood glucose levels. Furthermore, the results also showed that MA might modulate glucose metabolism partially through reducing insulin resistance in KK-A^y mice. Taken together, MA may hold great promise as a natural therapeutic agent for treatment of type 2 diabetes.