Solubilization of Dipropofol, an Antibacterial Agent, Using Saccharide and Ascorbic Acid

Masahiro Ogata; Kentaro Oka; Masako Seki; Midori Hoshi; Hirokatsu Takatsu; Tadahiko Mashino; Shiro Urano; Toyoshige Endo

doi:10.1248/bpb.30.1565

Notes

Solubilization of Dipropofol, an Antibacterial Agent, Using Saccharide and Ascorbic Acid

Masahiro Ogata, Kentaro Oka, Masako Seki, Midori Hoshi, Hirokatsu Takatsu, Tadahiko Mashino, Shiro Urano, Toyoshige Endo

著者情報

キーワード: dipropofol, monosaccharide, ascorbic acid, solubilization

ジャーナルフリー

2007 年 30 巻 8 号 p. 1565-1568

DOI https://doi.org/10.1248/bpb.30.1565

詳細

抄録

Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

責任著者(Corresponding author)

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