Bioactive Constituents from Chinese Natural Medicines. XXXIII.  Inhibitors from the Seeds of Psoralea corylifolia on Production of Nitric Oxide in Lipopolysaccharide-Activated Macrophages

Hisashi Matsuda; Sachie Kiyohara; Sachiko Sugimoto; Shin Ando; Seikou Nakamura; Masayuki Yoshikawa

doi:10.1248/bpb.32.147

Notes

Bioactive Constituents from Chinese Natural Medicines. XXXIII. Inhibitors from the Seeds of Psoralea corylifolia on Production of Nitric Oxide in Lipopolysaccharide-Activated Macrophages

Hisashi Matsuda, Sachie Kiyohara, Sachiko Sugimoto, Shin Ando, Seikou Nakamura, Masayuki Yoshikawa

著者情報

キーワード: Psoralea corylifolia, inhibitor, nitric oxide production, macrophage, prenylated flavonoid

ジャーナルフリー

2009 年 32 巻 1 号 p. 147-149

DOI https://doi.org/10.1248/bpb.32.147

詳細

抄録

The methanolic extract from the seeds of Psoralea corylifolia was found to inhibit production of nitric oxide (NO) in lipopolysaccharide-activated mouse peritoneal macrophages. Among the isolated compounds, bavachinin (IC₅₀=26 μM), isobavachalcone (17 μM), neobavaisoflavone (ca. 29 μM), corylifol A (ca. 21 μM), and psoralidin (ca. 23 μM) significantly inhibited the accumulation of nitrite (NO₂⁻) as a marker of production of NO. Bakuchiol, which is mainly contained in the extract, also showed weak activity at 10 μM, but cytotoxic effects were observed more than 30 μM.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）