Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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11-Tungstophosphate with Iron(II) and Hydrogen Peroxide Efficiently Detached Bacterial Biofilm
Yutaka TajimaRie TakagiTamiko NakajimaToshiro YasudaYoshihiko Kominato
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2009 年 32 巻 10 号 p. 1783-1789

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An attempt was made to detach bacterial biofilm, formed by Staphylococcus epidermidis, by using hydrogen peroxide (H2O2) and tungsten compounds. When iron(II) (Fe2+) was mixed with undecatungstophosphate ([PW11O39]7−) and then H2O2, the resulting mixture was able to totally remove the biofilm probably because of co-generation of 1O2 and ·OH. A mixture of undecatungstosilicate ([SiW11O39]8−) and Fe2+ (or Cu2+) also gave a good result, but their catalytic activities for producing ·OH (or 1O2) were rather weak. An electron microscopic study showed that almost nothing was visible on the surface of a biofilm-coated glass after treatment with 1mM [PW11O39]7−+1 mM Fe2+ and 500 mM H2O2 (incubated for 1 h at 37 °C).
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© 2009 The Pharmaceutical Society of Japan
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