Effects of Inhibiting the Proteasomal Degradation of Estrogen Receptor α on Estrogen Receptor α Activation under Hypoxic Conditions

Yeo Myeong Park; Jung Yoon Cho; Young Do Koo; Young Joo Lee

doi:10.1248/bpb.32.2057

Notes

Effects of Inhibiting the Proteasomal Degradation of Estrogen Receptor α on Estrogen Receptor α Activation under Hypoxic Conditions

Yeo Myeong Park, Jung Yoon Cho, Young Do Koo, Young Joo Lee

著者情報

キーワード: estrogen, estrogen receptor, hypoxia, proteasome inhibition

ジャーナルフリー

2009 年 32 巻 12 号 p. 2057-2060

DOI https://doi.org/10.1248/bpb.32.2057

詳細

抄録

Hypoxia, which is intimately associated with the biology of breast carcinomas, modulates the level of estrogen receptor (ER) α expression and transactivation. We investigated the effect of blocking ER degradation on ERα-mediated transactivation under hypoxic conditions using the proteasome inhibitor MG132. Pretreatment with MG132 blocked hypoxia-induced degradation of ERα protein. Our data imply that ERα proteasomal inhibition is linked to receptor transactivation under hypoxia.

責任著者(Corresponding author)

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