Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice
Nobuaki EgashiraRyoko OkunoAtsunori ShirakawaMasaki NagaoKenichi MishimaKatsunori IwasakiRyozo OishiMichihiro Fujiwara
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2012 Volume 35 Issue 3 Pages 376-379

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Abstract

We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

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© 2012 The Pharmaceutical Society of Japan
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