Notes
Locomotor-Reducing Effects and Structural Characteristics of Inhaled Zerumbone and Tetrahydrozerumbone Derivatives
2014 年 37 巻 9 号 p. 1559-1563
詳細
2014 年 37 巻 9 号 p. 1559-1563
Zerumbone 1 is an 11-membered cyclic sesquiterpene obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the structure–activity relationship of 1, α-humulene (2), tetrahydrozerumbone stereoisomers (3–5), and tetrahydrozerumbone derivatives (6–9). The oxygen-containing functional groups and the configurations at C1 and C2 contributed to the spontaneous locomotor activity reduction of zerumbone 1 and derivatives 2–9.
