抄録
The effect of baclofen on static γ-activity enhanced by pinna pinching was compared with some of centrally acting muscle relaxants (chlorpromazine, mephenesin and diazepam) in the anesthetized rat. Baclofen (0.5-2 mg/kg, i.v.) showed only a little effect on the static γ-activity. At a higher dose of 5 mg/kg, the drug showed a marked depressant effect on the static γ-activity, although this dose was much higher than that required to depress spinal reflex activity. On the other hand, chlorpromazine, mephenesin and diazepam depressed the static γ-activity at lower doses than those required to depress spinal reflex activity. From these results, it is concluded that the depressant action of baclofen on the static γ-activity has only a little contribution to the muscle relaxant action and therapeutic effectiveness of the drug.
