SODIUM ION-DEPENDENCY OF TAURINE-INDUCED ENHANCEMENT OF DRUG ABSORPTION FROM RAT STOMACH IN SITU

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The enhancement of aspirin and o-ethoxybenzoic acid (but not salicylamide) absorption by taurine was cancelled by the complete replacement of NaCl with mannitol or by the presence of ouabain in the NaCl medium. It seems to require Na⁺. Homotaurine showed a similar mode of action, while the effect of glycine, the other absorption promoter, on both aspirin and salicylamide absorption was independent of the presence of Na⁺. The mechanism of action of these amino acid-like absorption promoters is speculated to be not uniform.