1993 Volume 16 Issue 10 Pages 1057-1059
Inter-individual differences of drug plasma concentration were recognized in male Sprague-Dawley (SD) rats after a p.o. or i.v. administration of (+)-MPPB. Rats could be divided into two phenotypes, the rapid-metabolizing group (RM) and the slow-metabolizing group (SM). The hepatic clearance (CLliver) of RM was about 10 times larger than that of SM. Outbred SD(♂, ♀), and Wister(♂) rats were mixtures of RM and SM. On the other hand, all inbred Lewis(♂) rats were RM, and all inbred F344(♂) and ACl(♂) rats were SM.