Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
INTER-INDIVIDUAL DIFFERENCES OF (+)-4-[4-(4-METHYLPHENYL)PHENYLMETHOXY-1-PIPERIDINYL]BUTYRIC ACID ((+)-MPPB) DISPOSITION IN RATS
Eiji TAKAHARAOsamu NAGATAHideo KATOShigeru OHTAMasaaki HIROBE
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1993 Volume 16 Issue 10 Pages 1057-1059

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Abstract

Inter-individual differences of drug plasma concentration were recognized in male Sprague-Dawley (SD) rats after a p.o. or i.v. administration of (+)-MPPB. Rats could be divided into two phenotypes, the rapid-metabolizing group (RM) and the slow-metabolizing group (SM). The hepatic clearance (CLliver) of RM was about 10 times larger than that of SM. Outbred SD(♂, ♀), and Wister(♂) rats were mixtures of RM and SM. On the other hand, all inbred Lewis(♂) rats were RM, and all inbred F344(♂) and ACl(♂) rats were SM.

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© The Pharmaceutical Society of Japan
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