抄録
The effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats were studied. Following the administration of 2, 5-dimethylpyrazine (100 mg/kg, s.c.), the weight of prostate and seminal vesicles, as well as testosterone levels in plasma were significantly decreased. One isomer of dimethylpyrazine, 2, 6-dimethylpyrazine (100 mg/kg, s.c.), affected only the seminal vesicles, while 2, 3-dimethylpyrazine had no influence on accessory reproductive organs. Following administration of 100 mg/kg of 2, 5-dimethylpyrazine, acid phosphatase activity in the prostate and fructose content in the seminal vesicles were also significantly decreased compared with tissues from vehicle-treated animals. Weight of the testes and acid phosphatase activity therein were not affected following the administration of 2, 5-dimethylpyrazine, nor were numbers of spermatozoa in the epididymis. These results showed that 2, 5-dimethylpyrazine induced decrease in prostate and seminal vesicle weight by inhibiting testosterone uptake and reducing plasma testosterone levels.
