Author's Organization：Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
A screening method for anti-osteoporotics using ovariectomized rats was designed using a compact method to monitor the bone density. It was found that ovariectomy (OVX) of Wister female rats (11 weeks old) induced acute and focal osteopenia within 2 weeks, which responded well to intermittent salmon calcitonin (SCT : 5 and 20 U/kg, s.c., every other day) employed as the standard anti-osteoporotic and injected up to 4 weeks with or without a delay of 2 weeks after OVX.
