Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Polysaccharides in Fungi. XXXIV. A Polysaccharide from the Fruiting Bodies of Amanita muscaria and the Antitumor Activity of Its Carboxymethylated Product
木方 正吉田 勲桂川 昌巳佐久嶋 美穂/Shigeo UKAI
著者情報
ジャーナル フリー

1994 年 17 巻 11 号 p. 1460-1462

詳細
抄録

A water-insoluble, alkali-soluble, glucan (AM-APP), [α]D + 160° in 0.4м NaOH, was isolated from the alkaline extract of the fruiting bodies of Amanita muscaria. The results of chemical and spectroscopic investigations indicate that AM-APP is a linear (1→3)-α-D-glucan with a molecular weight estimated by gel chromatography of about 42000. Its carboxymethylated product (AM-APP-CM) showed potent antitumor activity against sarcoma 180 in mice, although the native polysaccharide (AM-APP) had little effect. The distribution of carboxymethyl groups in the molecule was analyzed by gas chromatography and mass spectrometry. The degree of substitution of carboxymethyl groups was 0.95 and the substituents were located at O-2, at O-4, at O-6, at O-2 and O-6, and at O-4 and O-6 on glucose.

著者関連情報
© The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top