THREE ISOFORMS OF PLATELET-DERIVED GROWTH FACTORS ALL HAVE THE CAPABILITY TO INDUCE ANGIOGENESIS IN VIVO

Abstract

Three isoforms of platelet-derived growth factors (PDGFs) composing of AA, AB and BB chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay system involving the chorioallantoic membrane of chick embryo. The order of potency was BB>AB=AA. They, however, failed to stimulate proliferation of vascular endothelial cells, suggesting that their effects are indirect. These data suggest the possibility that three PDGF isoforms are indirect angiogenic factors.