Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Interaction of Some Plant Heterocyclic β-Substituted Alanines with Rat Brain N-Methyl-D-aspartate (NMDA) Receptors
池上 文雄草間(江口) 國子杉山 栄美渡邊 和子/ 村越 勇Isamu MURAKOSHI
ジャーナル フリー

1995 年 18 巻 2 号 p. 360-362


The neuropharmacological actions of some plant heterocyclic β-substituted alanines on rat brain N-methyl-D-aspartate (NMDA) receptors were studied. Of the compounds tested, 3-N-oxalyl-L-2, 3-diaminopropanopic acid (β-ODAP), the causal agent of human neurolathyrism, exhibited an inhibitory activity on the NMDA receptor binding assay at a relatively high concentration (IC50 : 4.7×10-5M). The biochemical precursor of β-ODAP, β-(isoxazolin-5-on-2-yl)-L-alanine (BIA) was inactive in this assay. These results suggest that β-ODAP, the neurotoxin of Lathyrus sativus, in addition to its excitatory action on α-amino-3-hydroxy-5-methylisoxazole-4-propanoic acid (AMPA) receptors, also has neurotoxic potential through its action on NMDA receptors.

© The Pharmaceutical Society of Japan
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