Author's Organization：College of Pharmacy, Pusan National University College of Pharmacy, Pusan National University Department of Biology, Faculty of Science, Kyushu University Faculty of Pharmaceutical Sciences, University of Tokyo Faculty of Pharmaceutical Sciences, University of Tokyo College of Pharmacy, Pusan National University
Published: March 15, 1995Received: September 30, 1994Available on J-STAGE: April 10, 2008Accepted: November 11, 1994
Advance online publication: -
Revised: -
We purified and characterized a sapecin homologue, named holotricin 1, from the hemolymph of immunized larvae of a coleopteran insect, Holotrichia diomphalia. We determined its complete amino acid sequence and three disulfide pairs. Holotricin 1 consisted of 43 amino acid residues and showed potent antibacterial activity against gram-positive bacteria, but antibacterial activity against gram-negative bacteria was not obvious.
