EFFECT OF LIPOPHILICITY OF TRICHOSPORIN-Bs ON ION-CHANNEL FORMATION AND CATECHOLAMINE-RELEASING ACTIVITY

Yasuo NAGAOKA; Akira IIDA; Takeshi KAMBARA; Eiichi TACHIKAWA; Koji ASAMI; Tetsuro FUJITA

doi:10.1248/bpb.18.640

Yasuo NAGAOKA, Akira IIDA, Takeshi KAMBARA, Eiichi TACHIKAWA, Koji ASAMI, Tetsuro FUJITA

Author information

Keywords: trichosporin, Trichoderma polysporum, peptaibol α-aminoisobutyric acid, ion-channel, catecholamine

JOURNAL FREE ACCESS

1995 Volume 18 Issue 4 Pages 640-642

DOI https://doi.org/10.1248/bpb.18.640

Details

Abstract

A series of peptaibols, trichosporin (TS) -Bs, induced voltage-activated conductance in lipid bilayer membranes and catecholamine secretion from bovine adrenal chromaffin cells. The order of activities is the same as that of the lipophilicity rank of TS-Bs derived from the reversed-phase HPLC capacity factors.

Corresponding author

Register with J-STAGE for free!