DOES BACITRACIN HAVE AN ABSORPTION-ENHANCING EFFECT IN THE INTESTINE?

Shinji GOTOH; Reiko NAKAMURA; Mizue NISHIYAMA; Takuya FUJITA; Akira YAMAMOTO; Shozo MURANISHI

doi:10.1248/bpb.18.794

Shinji GOTOH, Reiko NAKAMURA, Mizue NISHIYAMA, Takuya FUJITA, Akira YAMAMOTO, Shozo MURANISHI

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Keywords: protease inhibitor, bacitracin, fluorescein isothiocyanate dextran, phenol red, intestinal absorption, absorption enhancement

JOURNAL FREE ACCESS

1995 Volume 18 Issue 5 Pages 794-796

DOI https://doi.org/10.1248/bpb.18.794

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Abstract

We studied the absorption enhancement effects of three types of protease inhibitors, aprotinin, bacitracin and soybean trypsin inhibitor, in the rat intestine. Of these protease inhibitors, bacitracin enhanced the absorption of FD-4 and phenol red from the rat small and large intestine without mucosal toxicity. Thus, it was suggested that bacitracin has not only a protease-inhibitory but also an absorption-enhancing capability.

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