Structure-Activity Correlationship and Strain Specificity of Polyoxometalates in Anti-human Immunodeficiency Virus Activity

抄録

The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1_HTLV-IIIBand HIV-1_SF-2H). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacumary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1_HTLV-IIIBactivity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1_HTLV-IIIBactivity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1_SF-2Hto a much higher extent compared with HIV-1_HTLV-IIIB-related ones. The difference between the spectra of anti-HIV-1_HTLV-IIIBactivity and the specificity for HIV-1_SF-2Hmight result from differential structural requirements in these functions.