Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Thermally Gelling Poloxamine Synperonic T908 Solution as a Vehicle for Rectal Drug Delivery
Shozo MIYAZAKIMasako ODAMasahiko TAKADADavid ATTWOOD
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1995 Volume 18 Issue 8 Pages 1151-1153

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Abstract

Thermally reversible gels of the block copolymer, Synperonic T908, have been evaluated as vehicles for the rectal administration of indomethacin. Prolonged plasma levels of indomethacin following rectal administration in such gels was observed with the 40% w/w Synperonic T908 gels when compared with commercial suppositories. The release rate decreased with an increase in gel concentration over the range 30% to 40% w/w. Histological observation showed no damage to the rectal mucosal membrane in animals at 6h after the administration of a 40% w/w gel.

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© The Pharmaceutical Society of Japan
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