Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Application of Curdlan to Controlled Drug Delivery. III. Drug Release from Sustained Release Suppositories in Vitro
Motoko KANKEEmi TANABEHirokazu KATAYAMAYoko KODAHironori YOSHITOMI
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JOURNALS FREE ACCESS

1995 Volume 18 Issue 8 Pages 1154-1158

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Abstract

The use of curdlan, a natural β-1, 3-glucan, in the preparation of sustained release suppositories was studied in vitro. To prepare the suppositories, indomethacin, prednisolone or salbutamol sulfate was mixed with curdlan gel. Preparation conditions, including heating time and curdlan concentrations of 5 and 10%, had little effect on the drug release. The tonicity (hypotonic or isotonic) of the media for the suppository preparation and for in vitro drug release study also had little effect on drug release. However, the heating temperature during gel preparation, the drug amount in the suppository and the type of release media did affect drug release. It was found that drug release was sustained and diffusion-controlled in the three drugs. And finally, curdlan can be applicable for use in a sustained release suppository.

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