Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
PROPERTIES OF TRICHOSPORIN-B-VIa-INDUCED CATECHOLAMINE SECRETION FROM BOVINE ADRENAL CHROMAFFIN CELLS
Eiichi TACHIKAWASaburo TAKAHASHIKenzo MIZUMATakeshi KASHIMOTOYasuo NAGAOKAAkira IIDATetsuro FUJITA
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1995 Volume 18 Issue 8 Pages 1165-1167

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Abstract

Trichosporin (TS)-B-VIa, a peptide consisting of 19 amino acid residues and an amino alcohol, causes Ca2+-dependent secretion of catecholamines from bovine adrenal chromaffin cells. The TS-B-VIa-induced secretion was greater under alkaline conditions and at a temperature of 37°C compared with that at 21° or 30°C. It was not observed when the peptide was eliminated from the incubation medium. These results strongly suggest that the stimulatory effect of TS-B-VIa on the secretion is reversible and dependent on the temperature and pH of the incubation medium.

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