PROPERTIES OF TRICHOSPORIN-B-VIa-INDUCED CATECHOLAMINE SECRETION FROM BOVINE ADRENAL CHROMAFFIN CELLS

Eiichi TACHIKAWA; Saburo TAKAHASHI; Kenzo MIZUMA; Takeshi KASHIMOTO; Yasuo NAGAOKA; Akira IIDA; Tetsuro FUJITA

doi:10.1248/bpb.18.1165

立川英一, 高橋三郎, 水間謙三, 樫本威志, 長岡康夫, 飯田彰, 藤多哲朗

著者情報

キーワード: trichosporin, peptaibol, ion-channel, catecholamine secretion, chromaffin cell, Trichoderma polysporum

ジャーナルフリー

1995 年 18 巻 8 号 p. 1165-1167

DOI https://doi.org/10.1248/bpb.18.1165

詳細

抄録

Trichosporin (TS)-B-VIa, a peptide consisting of 19 amino acid residues and an amino alcohol, causes Ca²⁺-dependent secretion of catecholamines from bovine adrenal chromaffin cells. The TS-B-VIa-induced secretion was greater under alkaline conditions and at a temperature of 37°C compared with that at 21° or 30°C. It was not observed when the peptide was eliminated from the incubation medium. These results strongly suggest that the stimulatory effect of TS-B-VIa on the secretion is reversible and dependent on the temperature and pH of the incubation medium.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）