Antibacterial Activity of Some Garcinia Benzophenone Derivatives against Methicillin-Resistant Staphylococcus aureus

Munekazu IINUMA; Hideki TOSA; Toshiyuki TANAKA; Satiyo KANAMARU; Fujio ASAI; Yasuko KOBAYASHI; Kenichi MIYAUCHI; Ryoyu SHIMANO

doi:10.1248/bpb.19.311

Munekazu IINUMA, Hideki TOSA, Toshiyuki TANAKA, Satiyo KANAMARU, Fujio ASAI, Yasuko KOBAYASHI, Kenichi MIYAUCHI, Ryoyu SHIMANO

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Keywords: antibacterial activity, methicillin-resistant Staphylococcus aureus, benzophenone, Garcinia subelliptica, Garcinia purpurea

JOURNAL FREE ACCESS

1996 Volume 19 Issue 2 Pages 311-314

DOI https://doi.org/10.1248/bpb.19.311

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Abstract

Benzophenone derivatives, garcinol (1) and isogarcinol (2) isolated from the pericarps of Garcinia purpurea (Guttiferae), and xanthochymol (3) and a mixture of isoxanthochymol (4) cycloxanthochymol (5) from the pericarps of G. subelliptica were evaluated for their antibacterial activity against methicillin-resistant Staphylococcus aureus. Among them, 3 showed the lowest minimum inhibitory concentration at 3.1-12.5μg/ml. This concentration is nearly equal to that of the antibiotic, vancomycin.

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