Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Intraperitoneal Administration of Senegae Radix Extract and Its Main Component, Senegin-II, Affects Lipid Metabolism in Normal and Hyperlipidemic Mice
Hiroyuki MASUDAKen OHSUMIMami KAKOToshihiro MIURAYumi NISHIYAMAMomoyo ICHIMARUMasataka MORIYASUAtsushi KATO
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JOURNAL FREE ACCESS

1996 Volume 19 Issue 2 Pages 315-317

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Abstract

The hypolipidemic effect of Senegae Radix, i.e."Senega, "was investigated in normal and hyperlipidemic mice. The n-butanol fraction of the methanol extract of Senegae Radix (SN) (5mg/kg) significantly reduced the blood triglyceride level of normal mice 7h after intraperitoneal administration (p<0.05) and also significantly reduced the blood triglyceride level of cholesterol-fed mice under similar conditions (p<0.05). SN (5mg/kg) also reduced the blood triglyceride and cholesterol levels after repeated administration to cholesterol-fed mice. SN also decreased the blood triglyceride level in Triton-induced hyperlipidemia. It is suggested that this fraction contains one or more hypolipidemic components including the main triterpenoid glycoside, senegin-II, which significantly reduces the levels of blood triglycerides in normal mice.

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© The Pharmaceutical Society of Japan
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