Studies on Kochiae Fructus. V. Antipruritic Effects of Oleanolic Acid Glycosides and the Structure-Requirement

Hideaki MATSUDA; Yue DAI; Yasuko IDO; Toshiyuki MURAKAMI; Hisashi MATSUDA; Masayuki YOSHIKAWA; Michinori KUBO

doi:10.1248/bpb.21.1231

Hideaki MATSUDA, Yue DAI, Yasuko IDO, Toshiyuki MURAKAMI, Hisashi MATSUDA, Masayuki YOSHIKAWA, Michinori KUBO

著者情報

キーワード: Kochia scoparia, Momordica cochinchinensis, antipruritic effect, oleanolic acid 3-O-monodesmoside, compound 48/80-induced pruritic model, structure-requirement

ジャーナルフリー

1998 年 21 巻 11 号 p. 1231-1233

DOI https://doi.org/10.1248/bpb.21.1231

詳細

抄録

We examined the antipruritic effects of various oleanolic acid glycosides from natural medicines such as Kochiae Fructus (the fruit of Kochia scoparia SCHRAD.) and Momordicae Radix (the roots of Momordica cochinchinensis SPRENG.) using a compound 48/80-induced pruritic model in mice. Oleanolic acid 3-O-monodesmosides showed an antipruritic effect, while oleanolic acid 3, 28-O-bisdesmosides and their common sapogenol oleanolic acid lacked the activity. This evidence indicated that the 3-O-glycoside moiety and the 28-carboxyl group in oleanolic acid glycosides were essential for exhibiting the antipruritic effect. Furthermore, it was found that the 3-O-glucuronides showed more potent activity than the corresponding 3-O-glucosides.

責任著者(Corresponding author)

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