POTENT RETINOID SYNERGISTS WITH A DIPHENYLAMINE SKELETON

Kiminori OHTA; Motonori TSUJI; Emiko KAWACHI; Hiroshi FUKASAWA; Yuichi HASHIMOTO; Koichi SHUDO; Hiroyuki KAGECHIKA

doi:10.1248/bpb.21.544

Kiminori OHTA, Motonori TSUJI, Emiko KAWACHI, Hiroshi FUKASAWA, Yuichi HASHIMOTO, Koichi SHUDO, Hiroyuki KAGECHIKA

著者情報

キーワード: retinoid, retinoic acid, synergist, cell differentiation

ジャーナルフリー

1998 年 21 巻 5 号 p. 544-546

DOI https://doi.org/10.1248/bpb.21.544

詳細

抄録

4-[N-(5, 6, 7, 8-Tetrahydro-5, 5, 8, 8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibited weak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay. N-Alkylation of 5 caused decrease or loss or differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC₅₀ (SEC₅₀) values of DA023 (11, 1.6×10^-10 M) and DA113 (14, 1.4×10^-10 M) in the presence of 1.0×10^-10 M Am80 (2).

責任著者(Corresponding author)

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