抄録
Changes in the level of GSH and γ-Glutamylcysteine Synthetase (γ-GCS) activity with time were determined during regeneration of rat liver after partial hepatectomy. The GSH level and γ-GCS activity increased in regenerating rat liver, reaching a maximum (2.1- and 1.5-fold that in sham-operated controls) on day 2, respectively. Furthermore, γ-GCS mRNA expression increased within 24 h and reached maximum on day 2. These results suggest that the increased GSH level in regenerating rat liver after partial hepatectomy is associated with the transcriptional activation of γ-GCS gene and the sequence elevation in γ-GCS activity.
