A New Cytotoxic 2H-Pyran Compound Produced by Acid Treatment of the Fermentation Broth of Streptomyces Sp.

Chisato NOSAKA; Setsuko KUNIMOTO; Thoru MASUDA; Michiyo OHSONO; Hironobu IINUMA; Toshio TSUCHIDA; Masa HAMADA; Tomio TAKEUCHI

doi:10.1248/bpb.22.546

Chisato NOSAKA, Setsuko KUNIMOTO, Thoru MASUDA, Michiyo OHSONO, Hironobu IINUMA, Toshio TSUCHIDA, Masa HAMADA, Tomio TAKEUCHI

著者情報

キーワード: Streptomyces, sphydrofuran, 2-methyl-4-(1-glyceryl) furan, 2H-pyran

ジャーナルフリー

1999 年 22 巻 5 号 p. 546-548

DOI https://doi.org/10.1248/bpb.22.546

詳細

抄録

A new cytotoxic substance was isolated following acid treatment of fermented broth of a Streptomyces strain numbered MJ915-WF12. The structure was elucidated by spectroscopic analyses to be 5-dihydro-4-formyl-6-hydroxy-2-hydroxymethyl-6-methyl-2H-pyran. It was thought to be generated by dehydration and ring reformation of the precursor material in cultured broth by acid.

責任著者(Corresponding author)

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