アルミニウムおよびマンガンの慢性曝露がマウスの行動に及ぼす影響

抄録

Aluminium (Al) and manganese (Mn) are known to have neurotoxic effects. The risk of excessive intake of Al and Mn is increased by trace elements in food and in dietary supplements. Mn and Al in dietary supplements were measured using atomic absorption spectrophotometry. Some supplements of botanical or animal origin contained high concentrations of Al and Mn. To study the effects of chronic exposure to Al and/or Mn on animal behavior, these substances were administered to aged mice for 43 weeks in drinking water. The mice were divided into seven groups: (1) control; (2) 1000 mgAl/L aluminium lactate solution (AL1000); (3) 10 mgAl/L aluminium lactate solution (AL10); (4) 1000 mgMn/L manganese chloride solution (MC1000); (5) 10 mgMn/L manganese chloride solution (MC10); (6) 500 mgAl/L aluminium lactate plus 500 mgMn/L manganese chloride solution (AL+MC500) (7) 10 mgAl/L aluminium lactate plus 10 mgMn/L manganese chloride solution (AL+MC10). The wheel-running activity of the mice was monitored twice a week in 10 min segments for 43 weeks. Chronic exposure to AL10, MC10 and AL+MC10 was found to inhibit wheel-running activity.