2015 年 26 巻 3 号 p. 124-133
Iron (Fe) and zinc (Zn) are apt to be depleted in humans at the same time because of common food sources and common absorption inhibitors. In fact, there were several reports on the occurrence of simultaneous deficiency of Fe and Zn in some populations. Although many researchers investigated single deficiency of Fe or Zn, their interactions on biochemical and biological parameters are not clearly defined. We tried to determine the effect of dietary Fe and/or Zn deficiencies on rectal temperature, blood pressure, body water distribution, plasma erythropoietin level, blood biochemical parameters (lipids, protein and enzyme activity) and plasma mineral concentrations using experimental rats as a model for human zinc metabolism. Effects of combined deficiency of Fe and Zn were significantly different from those of single deficiency of Fe or Zn especially in body temperature. Body temperature was decreased by single deficiency of Fe or Zn, but combined deficiency of Fe and Zn did not change the temperature. Blood pressure is most decreased by combined deficiency of Fe and Zn, and plasma aldosterone concentration is also decreased by it. Fe and Zn deficiencies affect plasma Fe and Zn concentrations each other. Hence, future advancement of investigations on trace element interaction especially Fe and Zn is awaited.