抄録
Subcutaneous injection of benzene, 2 ml/kg daily is per formed for 21 days on male Wister rats. Cellular changes of the bone marrow are studied serially in the light and electron microscopic levels. As signs of cellular injury, swelling of the mitochondria, severe dilatation of the membrane system such as rough surfaced endoplasmic reticulum (rER), smooth surfaced endoplasmic reticulum (sER) and Golgi complexes, expansion of outer nuclear membrane, and swelling of the specific granules with clear content are revealed. Existence of membrane free ribosomes even in the mature leukocytes is also seen, and which phenomenon is considered as the maturation dissociation. Severely desintegrated haematopoietic cells are observed mostly caught within the phagocytic reticular cells. The mechanism through which bone marrow are injured by benzene is discussed. Reticulo-endothelial structure of the bone marrow in normal and benzene intoxicated animals is also studied. Reticulo-endothelial cells of the bone marrow are classified in to three types, among which special attention is paid to the subsinusoidally lying reticular cells. This particular cells show lower phagocytic activity, and often transform into the fat cells.
