1997 年 68 巻 1 号 p. 86-90
The effects of sera from calves receiving Burdizzo castration or intravenous ACTH injection (100 IU a head) and then developing an acute plasma cortisol rise on the bovine lymphocyte and neutrophil function were examined with a view to elucidating whether these treatments can induce the animals to develop a serum immunomodulatory effect on those cells. When incubated with bovine lymphocytes, the sera from ACTH-treated calves induced a significant suppression (p<0.05) of concanavalin A-induced blastogenesis. The sera from castrated animals showed similar suppression but not significantly. It can be supposed that the serum lymphocyte suppression might have been related, at least in part, to elevated cortisol concentrations due to the treatments. Those sera, however, did not affect the luminol-dependent chemiluminescence activity, a bactericidal parameter, of bovine neutrophils.