Intravenous Administration of Nifekalant Hydrochloride for the Prevention of Ischemia-Induced Ventricular Tachyarrhythmia in Patients With Renal Failure Undergoing Hemodialysis

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Excretion in the urine is an important pathway for the elimination of nifekalant hydrochloride (NIF), a novel class III antiarrhythmic agent. Three patients with renal failure were undergoing hemodialysis and receiving NIF for the prevention of ischemia-induced ventricular tachyarrhythmia. Because NIF is not dialyzed, dose adjustment at relatively low concentrations was required, with monitoring of the QT interval. (Circ J 2003; 67: 898 - 900)