Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Effect of Distal Protection Device on the Microvascular Integrity in Acute Myocardial Infarction During Primary Percutaneous Coronary Intervention
Myeong-Ho YoonSeung-Jea TahkSo-Yeon ChoiTae-Young ChoiByoung-Joo ChoiJung-Hyun ChoiSang-Yong YooSung-Gyun AhnZhen-Guo ZhengGyo-Seung HwangJoon-Han Shin
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2006 Volume 70 Issue 10 Pages 1284-1289

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Abstract

Background The use of a distal protection device during primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) may preserve the microvascular integrity of the myocardium. Methods and Results A total of 58 consecutive patients with AMI, who had undergone primary PCI within 24 h after onset, were enrolled (30 patients with the PercuSurge GuardWire ® System, 28 without). The coronary flow velocity reserve was not different between the 2 groups. In patients with a distal protection device, the post-PCI Thrombolysis In Myocardial Infarction myocardial perfusion grades (TMP) were more favorable (TMP 0/1: 13.3%, TMP 2: 23.3%, TMP 3: 63.4% vs TMP 0/1: 35.7%, TMP 2: 35.7%, TMP 3: 28.6%, p=0.023). These patients also exhibited lower basal and hyperemic microvascular resistance index levels (4.33±2.22 vs 5.55±2.36 mmHg · cm-1 · s, p=0.047; 2.39±1.40 vs 3.14±1.36 mmHg · cm-1 · s, p=0.045, respectively), and longer basal diastolic deceleration time (679±273 vs 519±289 ms, p=0.035) after PCI. Conclusion Distal protection with the PercuSurge GuardWire® system may effectively preserve the microvascular integrity of the myocardium during primary PCI in AMI patients. (Circ J 2006; 70: 1284 - 1289)

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© 2006 THE JAPANESE CIRCULATION SOCIETY
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