Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Heart Failure
Improvement of Quality of Life With Nocturnal Oxygen Therapy in Heart Failure Patients With Central Sleep Apnea
Shigetake SasayamaTohru IzumiMasunori MatsuzakiAkira MatsumoriHidetsugu AsanoiShin-ichi MomomuraYoshihiko SeinoKenji UeshimaThe CHF-HOT Study Group
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2009 Volume 73 Issue 7 Pages 1255-1262


Background: Previously, we reported the benefit of 12 weeks of home oxygen therapy (HOT) in patients with central sleep apnea (CSA) and heart failure (HF). In the present study, we attempted to confirm the sustained efficacy of HOT in the long term treatment. Methods and Results: In the present study, 51 patients with CSA and HF (New York Heart Association (NYHA) functional classes II-III) were assigned to receive either nocturnal oxygen (HOT group n=26) or usual breathing (control group n=25) for 52 weeks. In the HOT group, greater reduction in apnea and hypopnea and greater increase in nocturnal oxygen saturation were observed. These changes were associated with greater improvement in the Specific Activity Scale (0.82 ±1.17 vs -0.11 ±0.73 Mets, P=0.009) in NYHA functional class (P=0.007) and in ejection fraction (5.45 ±11.94 vs 1.28 ±9.77%). There were no significant differences in the cardiac event rates; however, the later divergence favored the HOT group. Conclusions: The 52-week HOT was well tolerated and the benefit observed in the 12-week trial was sustained over a prolonged period of time. HOT was considered to be a valuable non-pharmacological therapeutic addition for HF patients with CSA. (Circ J 2009; 73: 1255-1262)

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