Differences Between Rosuvastatin and Atorvastatin in Lipid-Lowering Action and Effect on Glucose Metabolism in Japanese Hypercholesterolemic Patients With Concurrent Diabetes – Lipid-Lowering With Highly Potent Statins in Hyperlipidemia With Type 2 Diabetes Patients (LISTEN) Study –

Hisao Ogawa; Kunihiko Matsui; Yoshihiko Saito; Seigo Sugiyama; Hideaki Jinnouchi; Masahiro Sugawara; Izuru Masuda; Hisao Mori; Masako Waki; Minoru Yoshiyama; Hirotaka Watada

doi:10.1253/circj.CJ-14-0810

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Differences Between Rosuvastatin and Atorvastatin in Lipid-Lowering Action and Effect on Glucose Metabolism in Japanese Hypercholesterolemic Patients With Concurrent Diabetes

– Lipid-Lowering With Highly Potent Statins in Hyperlipidemia With Type 2 Diabetes Patients (LISTEN) Study –

Hisao Ogawa, Kunihiko Matsui, Yoshihiko Saito, Seigo Sugiyama, Hideaki Jinnouchi, Masahiro Sugawara, Izuru Masuda, Hisao Mori, Masako Waki, Minoru Yoshiyama, Hirotaka Watada

Author information

Hisao Ogawa
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Deputy Director General of the Hospital, National Cerebral and Cardiovascular Center
Kunihiko Matsui
Department of Community Medicine, Kumamoto University Hospital
Yoshihiko Saito
First Department of Internal Medicine, Nara Medical University
Seigo Sugiyama
Jinnouchi Hospital
Hideaki Jinnouchi
Jinnouchi Hospital
Masahiro Sugawara
Sugawara Clinic
Izuru Masuda
Medical Examination Center, Takeda Hospital
Hisao Mori
Yokohama Sotetsu Bldg, Clinic of Internal Medicine
Masako Waki
Department of Internal Medicine, Shizuoka City Hospital
Minoru Yoshiyama
Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University
Hirotaka Watada
Department of Metabolism and Endocrinology, Graduate School of Medicine, Juntendo University

Keywords: Hypercholesterolemia, Statins, Type 2 diabetes mellitus

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Supplementary material

2014 Volume 78 Issue 10 Pages 2512-2515

DOI https://doi.org/10.1253/circj.CJ-14-0810

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Abstract

Background:Little is known about the differences between standard-dose statins effects on glucose level and lipids in Japanese patients with diabetes mellitus (DM).Methods and Results:The 1,049 patients were randomly assigned to either the rosuvastatin group or atorvastatin group. There were no significant differences between the 2 groups in the effect on non-high-density lipoprotein cholesterol (non-HDL-C) and HbA1c at 12 months. However, physicians tended to switch to more intensive therapy for DM in the atorvastatin group.Conclusions:Rosuvastatin 5 mg and atorvastatin 10 mg have a similar lowering effect on non-HDL-C, but might be different in terms of adverse effect on glucose levels. (Circ J 2014; 78: 2512–2515)

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