Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Arrhythmia/Electrophysiology
Increased Variability of the Coupling Interval of Premature Ventricular Contractions as a Predictor of Cardiac Mortality in Patients With Left Ventricular Dysfunction
Chan-Hee LeeKyu-Hwan ParkJong-Ho NamJeon LeeYoon-Jung ChoiEun-Jung KongHyun-Wook LeeJang-Won SonUng KimJong-Seon ParkYoung-Jo KimDong-Gu Shin
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

2015 Volume 79 Issue 11 Pages 2360-2366

Details
Abstract

Background:The characteristics and prognostic value of the variability of premature ventricular contraction (PVC) coupling intervals (CIs) for cardiac mortality are not yet decisive.Methods and Results:In 133 consecutive patients (58±14 years old, 53 women) who had left ventricular dysfunction (LVD: ejection fraction <50%) and frequent PVCs (≥10/h) who underwent 24-h ambulatory electrocardiography (AECG) recording and 123I-metaiodobenzylguanidine myocardial single-photon emission computed tomography simultaneously, the heart rate turbulence onset, slope, and T-wave alternans were analyzed from the 24-h AECG. The CI of the PVCs (MEANNV), standard deviation of the CI of the PVCs (SDNV) as an index of the variability of the PVC CI, and their ratio to the preceding N-N intervals (SDNV/SDNN) were calculated from constructed Poincaré plots using the annotated 24-h AECG QRS data. The primary endpoint was cardiac mortality. The mean follow-up period was 63 months. Among 133 patients, 114 survived (group 1) and 19 (14%, group 2) died during the follow-up. The MEANNVand SDNVwere higher in group 2 (539±104 vs. 599±114 ms, P=0.021; 64±34 vs. 83±37 ms, P=0.022, respectively). The SDNV, PVC count, and delayed heart/mediastinum ratio remained as significant predictors of cardiac mortality in the binary logistic regression analysis.Conclusions:These results suggest that the SDNVcould be another adjunctive parameter for predicting cardiac mortality in LVD. (Circ J 2015; 79: 2360–2366)

Information related to the author
© 2015 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
feedback
Top