Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Heart Failure
Impact of Peripheral Artery Disease on Prognosis in Hospitalized Heart Failure Patients
Yuichi NakamuraHiroyuki KuniiAkiomi YoshihisaMai TakiguchiTakeshi ShimizuHiroyuki YamauchiShoji IwayaTakashi OwadaSatoshi AbeTakamasa SatoSatoshi SuzukiMasayoshi OikawaAtsushi KobayashiTakayoshi YamakiKoichi SugimotoKazuhiko NakazatoHitoshi SuzukiShu-ichi SaitohYasuchika Takeishi
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Supplementary material

2015 Volume 79 Issue 4 Pages 785-793

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Abstract

Background:The impact of peripheral artery disease (PAD) on heart failure (HF) prognosis remains unclear.Methods and Results:A total of 388 consecutive decompensated HF patients were divided into 2 groups based on the presence of PAD: HF with PAD (PAD group, n=101, 26.0%) and HF without PAD (non-PAD group, n=287, 74.0%). We compared clinical features, echocardiographic parameters, cardiopulmonary exercise testing results, laboratory findings, as well as cardiac, non-cardiac, and all-cause mortality between the 2 groups. The PAD group, as compared with the non-PAD group, had (1) higher prevalence of coronary artery disease (40.6 vs. 27.5%, P=0.011) and cerebrovascular disease (34.7 vs. 18.2%, P=0.001); (2) higher tumor necrosis factor-α (1.82 vs. 1.49 pg/ml, P=0.023), C-reactive protein (0.32 vs. 0.19 mg/dl, P=0.045), and troponin T (0.039 vs. 0.021 ng/ml, P=0.019); (3) lower LVEF (42.4 vs. 48.5%, P<0.001); (4) lower peak V̇O2(13.4 vs. 15.9 ml·kg–1·min–1, P=0.001); and (5) higher V̇E/V̇CO2slope (38.8 vs. 33.7, P<0.001). On Kaplan-Meier analysis, cardiac, non-cardiac, and all-cause mortality were significantly higher in the PAD group than in the non-PAD group (P<0.05, respectively). On Cox proportional hazard analysis after adjusting for confounding factors, PAD was an independent predictor of cardiac and all-cause mortality (P<0.05, respectively) in HF patients.Conclusions:PAD was common and an independent predictor of cardiac and all-cause mortality in HF patients. (Circ J 2015; 79: 785–793)

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© 2015 THE JAPANESE CIRCULATION SOCIETY
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