Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Arrhythmia/Electrophysiology
Efficacy and Myocardial Injury With Subcutaneous Implantable Cardioverter Defibrillators – Computer Simulation of Defibrillation Shock Conduction –
Mahito NoroXin ZhuYoshinari EnomotoMasako AsamiRina IshiiYasutake ToyodaNaohiko SaharaTakahito TakagiYuriko NarabayasiHikari HashimotoNaoshi ItoShingo KujimeYasuhiro OikawaHiroyuki TatsunamiTsuyoshi SakaiKeijirou NakamuraTakao SakataKaoru Sugi
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2016 Volume 80 Issue 1 Pages 85-92

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Abstract

Background:Subcutaneous implantable cardiac defibrillator (S-ICD) systems have a lower invasiveness than traditional ICD systems, and expand the indications of ICD implantations. The S-ICD standard defibrillation shock output energy, however, is approximately 4 times that of the traditional ICD system. This raises concern about the efficacy of the defibrillation and myocardial injury. In this study, we investigated the defibrillation efficacy and myocardial injury with S-ICD systems based on computer simulations.Methods and Results:First, computer simulations were performed based on the S-ICD system configurations proposed in a previous study. Furthermore, simulations were performed by placing the lead at the left or right parasternal margin and the pulse generator in the superior and inferior positions (0–10 cm) of the recommended site. The simulated defibrillation threshold (DFT) for the 4 S-ICD system configurations were 30.1, 41.6, 40.6, and 32.8 J, which were generally similar to the corresponding clinical results of 33.5, 40.4, 40.1, and 34.3 J.Conclusions:The simulated DFT were generally similar to their clinical counterparts. In the simulation, the S-ICD system had a higher DFT but relatively less severe myocardial injury compared with the traditional ICD system. Further, the lead at the right parasternal margin may correspond to a lower DFT and cause less myocardial injury. (Circ J 2016; 80: 85–92)

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© 2016 THE JAPANESE CIRCULATION SOCIETY
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