Distribution of Anti-Factor Xa Activity in Patients on Edoxaban Therapy for Non-Valvular Atrial Fibrillation

Hiroyuki Osanai; Masayoshi Ajioka; Tomohiro Masutomi; Tasuku Kuwayama; Sota Ishihama; Maki Takahashi; Takahiro Kanbara; Yosuke Inoue; Yoshihito Nakashima; Hiroshi Asano; Kazuyoshi Sakai

doi:10.1253/circj.CJ-15-1281

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Distribution of Anti-Factor Xa Activity in Patients on Edoxaban Therapy for Non-Valvular Atrial Fibrillation

Hiroyuki Osanai, Masayoshi Ajioka, Tomohiro Masutomi, Tasuku Kuwayama, Sota Ishihama, Maki Takahashi, Takahiro Kanbara, Yosuke Inoue, Yoshihito Nakashima, Hiroshi Asano, Kazuyoshi Sakai

著者情報

キーワード: Anti-factor Xa activity, Atrial fibrillation, Edoxaban

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2016 年 80 巻 3 号 p. 745-747

DOI https://doi.org/10.1253/circj.CJ-15-1281

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Background:The distribution of anti-factor Xa activity (AXA) values in non-valvular atrial fibrillation (NVAF) patients on edoxaban therapy has not been fully elucidated.Methods and Results:The steady-state trough and peak AXA values were measured in 66 NVAF patients. The trough AXA value did not differ significantly between the 60-mg and the 30-mg OD groups (0.17±0.13 IU/ml vs. 0.12±0.11 IU/ml, respectively; P=0.17). Similarly, the peak AXA value did not differ significantly between the 2 groups (1.45±0.81 IU/ml vs. 1.25±0.48 IU/ml, respectively; P=0.26).Conclusions:Recommended dosing should be followed for sufficient efficacy of edoxaban. (Circ J 2016; 80: 745–747)

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