Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms
Deborah A. HowattMaya DajeeXiaojie XieJessica MoorleghenDebra L. RateriAnju BalakrishnanValdeci Da CunhaDouglas G. JohnsDavid E. GutsteinAlan DaughertyHong Lu
著者情報
ジャーナル フリー HTML 早期公開
電子付録

論文ID: CJ-17-0229

この記事には本公開記事があります。
詳細
抄録

Background:This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).

Methods and Results:Male C57BL/6 or apolipoprotein E−/−mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E−/−mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence.

Conclusions:MMP-9 deficiency augmented AngII-induced AAA.

著者関連情報
© 2017 THE JAPANESE CIRCULATION SOCIETY
feedback
Top