Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Comparison of Optical Flow Ratio and Fractional Flow Ratio in Stent-Treated Arteries Immediately After Percutaneous Coronary Intervention
Hiroki EmoriTakashi KuboYasutsugu ShionoYasushi InoKunihiro ShimamuraKosei TeradaTakahiro NishiDaisuke HigashiokaMasahiro TakahataTeruaki WadaManabu KashiwagiAmir Kh. M. KhalifaAtsushi TanakaTakeshi HozumiShengxian TuTakashi Akasaka
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Article ID: CJ-20-0661


Background:Optical flow ratio (OFR) is a recently developed method for functional assessment of coronary artery disease based on computational fluid dynamics of vascular anatomical data from intravascular optical coherence tomography (OCT). The purpose of this study was to investigate the relationship between OFR and fractional flow reserve (FFR) in stent-treated arteries immediately after percutaneous coronary intervention (PCI).

Methods and Results:The OFR and FFR were measured in 103 coronary arteries immediately after successful PCI with a stent. An increase in the OFR and FFR values within the stent was defined as in-stent ∆OFR and ∆FFR, respectively. The values of FFR and OFR were 0.89±0.06 and 0.90±0.06, respectively. OFR was highly correlated with FFR (r=0.84, P<0.001). OFR showed a good agreement with FFR, presenting small values of mean difference and root-mean-squared deviation (FFR–OFR: −0.01±0.04). In-stent ∆OFR showed a moderate correlation (r=0.69, P<0.001) and good agreement (in-stent ∆FFR – in-stent ∆OFR: 0.00±0.02) with in-stent ∆FFR.

Conclusions:OFR showed a high correlation and good agreement with FFR in stent-treated arteries immediately after PCI.

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