Effect of Electrolytes on the Catecholamine Secretion from the Adrenal Gland by Synthetic Angiotensin II. : A Study on Hypertension

Abstract

The present experiment consisted of the perfusion of the dog's left adrenal gland with Locke's solution containing varying concentrations of calcium, magnesium and potassium in respect to clarify the role of electrolytes in secretion of catecholamine from adrenal gland stimulated by angiotensin II. Two gammas of synthetic angiotensin II was administered from the lumboadrenal artery and catecholamine in blood was measured on the lumboadrenal vein before and after the administration. As a result, it was found that there exists on optimum concentration of calcium for the action of angiotensin II, that magnesium inhibits against the catecholamine secretion, and that potassium, at a large dose, can stimulate to the adrenal medulla like angiotensin II.