16 パーキンソン病（PD）の自律神経障害～全身とのクロストーク
PD/DLBの抗コリン薬と認知機能
2013 年 53 巻 11 号 p. 1389-1392
詳細
2013 年 53 巻 11 号 p. 1389-1392
Overactive bladder (OAB) is a common autonomic disorder due mostly to lesions in the micturition-inhibiting area (D1 dopaminergic pathway in the basal ganglia) in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). anticholinergic drugs are the mainstay in the treatment of OAB. However, since 1997, anticholinergic adverse events on the cognitive function have been recognized. Drugs with less lipophilic, less permeable through the blood-brain barrier are the choice in the treatment of OAB in elderly neurologic patients.
