Two Novel Cucurbitacins, Neocucurbitacins A and B, from the Brazilian Folk Medicine “Buchinha” (Luffa operculata) and Their Effect on PEBP2αA and OCIF Gene Expression in a Human Osteoblast-Like Saos-2 Cell Line

Nobuo KAWAHARA; Atsuyo KURATA; Takashi HAKAMATSUKA; Setsuko SEKITA; Motoyoshi SATAKE

doi:10.1248/cpb.49.1377

Communications to the Editor

Two Novel Cucurbitacins, Neocucurbitacins A and B, from the Brazilian Folk Medicine “Buchinha” (Luffa operculata) and Their Effect on PEBP2αA and OCIF Gene Expression in a Human Osteoblast-Like Saos-2 Cell Line

Nobuo KAWAHARA, Atsuyo KURATA, Takashi HAKAMATSUKA, Setsuko SEKITA, Motoyoshi SATAKE

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Keywords: neocucurbitacin, Luffa operculata, Buchinha, Cucurbitaceae, cucurbitacin, bone formation

JOURNAL FREE ACCESS

2001 Volume 49 Issue 10 Pages 1377-1379

DOI https://doi.org/10.1248/cpb.49.1377

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Abstract

Two novel cucurbitacins designated as neocucurbitacins A (1), possessing inhibitory activity of polyoma enhancer binding protein 2αA (PEBP2αA) and osteoclastogenesis-inhibitory factor (OCIF) gene expression in human osteoblast-like cells, and B (2) were isolated from the fruit of Luffa operculata. Their structures have been determined by extensive spectroscopic investigation.

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