Regioselective Biomimetic Oxidation of Etodolac with Iodosylbenzene Catalyzed by Halogenated and Perhalogenated Metalloporphyrins in Dichloromethane

Shive M.S. CHAUHAN; Srinivas A. KANDADAI; Bishwabhusan SAHOO

doi:10.1248/cpb.49.1375

Communications to the Editor

Regioselective Biomimetic Oxidation of Etodolac with Iodosylbenzene Catalyzed by Halogenated and Perhalogenated Metalloporphyrins in Dichloromethane

Shive M.S. CHAUHAN, Srinivas A. KANDADAI, Bishwabhusan SAHOO

Author information

Keywords: etodolac, halogenated and perhalogenated metalloporphyrin, iodosylbenzene, 4-hydroxyetodolac, 4-oxoetodolac

JOURNAL FREE ACCESS

2001 Volume 49 Issue 10 Pages 1375-1376

DOI https://doi.org/10.1248/cpb.49.1375

Details

Abstract

The biomimetic oxidation of etodolac, an anti-inflammatory drug (1) with iodosylbenzene catalyzed by 5,10,15,20-tetraaryl-porphyrinatoiron(III) chlorides TAPFe(III)Cl (7a—e) in dichloromethane gives 4-hydroxyetodolac (6) and 4-oxoetodolac (5) regioselectively in moderate yields.

Corresponding author

Register with J-STAGE for free!