Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Inhibitory Effects on HIV-1 Protease of Tri-p-coumaroylspermidine from Artemisia caruifolia and Related Amides
Chao-Mei MANorio NAKAMURAMasao HATTORI
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2001 Volume 49 Issue 7 Pages 915-917

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Abstract

From a methanol extract of Artemisia caruifolia, which showed a moderate inhibitory activity on HIV-1 protease in a preliminary screening, N1, N5, N10-tri-p-coumaroylspermidine and three dicaffeoylquinic acids were isolated. The former compound was found to appreciably inhibit HIV-1 protease. Of related amides which were chemically synthesized, N1, N5, N10, N14-tetra-p-coumaroylspermine and N1, N4, N7, N10, N13-penta-p-coumaroyltetraethylenepentamine inhibited HIV-1 protease more potently than N1, N5, N10-tri-p-coumaroylspermidine.

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© 2001 The Pharmaceutical Society of Japan
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