Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Anti-allergic Agents from Natural Sources (4): Anti-allergic Activity of New Phloroglucinol Derivatives from Mallotus philippensis (Euphorbiaceae)
Akihiro DaikonyaShigeki KatsukiJin-Bin WuSusumu Kitanaka
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2002 Volume 50 Issue 12 Pages 1566-1569


Two new phloroglucinol derivatives, mallotophilippen A (1) and B (2) were isolated from the fruits of Mallotus philippensis. These compounds were identified, using chemical and spectral data, as 1-[5,7-dihydroxy-2,2-dimethyl-6-(2,4,6-trihydroxy-3-isobutyryl-5-methyl-benzyl)-2H-chromen-8-yl]-2-methyl-butan-1-one and 1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-2-methyl-butan-1-one, respectively. They inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ). Furthermore, they inhibited histamine release from rat peritoneal mast cells induced by Compound 48/80. These results suggest that the novel phloroglucinol derivatives have anti-inflammatory effects.

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© 2002 The Pharmaceutical Society of Japan
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