Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Notes
A Novel Cytotoxic C-Methylated Biflavone, Taiwanhomoflavone-B from the Twigs of Cephalotaxus wilsoniana
Yao-Haur KuoShy-Yuan HwangLi-Ming Yang KuoYi-Ling LeeShyh-Yuan LiYa-Ching Shen
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2002 Volume 50 Issue 12 Pages 1607-1608

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Abstract

A novel C-methylated biflavone, taiwanhomoflavone-B (1), together with known compounds, 7,4′,7″-tri-O-methylamentoflavone, 6-C-methylnaringenin and apigenin-7-O-β-glucoside were isolated from an ethanolic extract of Cephalotaxus wilsoniana. The structure of 1 was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-B is cytotoxic with ED50 values of 3.8 and 3.5 μg/ml, against KB oral epidermoid carcinoma and Hepa-3B hepatoma cells, respectively.

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© 2002 The Pharmaceutical Society of Japan
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